Updated: June 8, 2023
LDN 101
A Brief Introduction to Low Dose Naltrexone
LDN’s Killer App?
A Tipping Point for LDN—November 2022
According to Reuters news service, interest in LDN for long COVID is spreading rapidly, not only to patients and research centers but also to the NIH. Also, a new study out of Dublin shows great promise for those suffering from long COVID.
Learn more in the LDN Editor's Blog, as well as on our LDN Clinical Trials page.
Following Up After 21 Years
LDN for Wegener's and Chronic Fatigue—February 8, 2022
Dear Dr. Gluck,
It has been about 21 years since we met on board Jan’s Barge the Etoile. Your LDN saved my life and we both have been feeling great since. Our doctor prescribed LDN to Charlotte after my wonderful recovery from Wegener's granulomatosis; and it turned out that she had been diagnosed years before with Chronic Fatigue Syndrome. After starting LDN her symptoms disappeared, but it was not until a few years ago that we realized it was also an autoimmune disease.
We always get our flu shots and of course we had our Moderna shots and booster, but we have not had a cold or felt sick since taking LDN. I celebrated my 82nd birthday Sunday with zooming with our two children; and Charlotte and I will be celebrating our 59th wedding anniversary tomorrow. We have suggested LDN to many folks that we have met that have had autoimmune diseases and many have tried it with great results.
We live in Florida most of the year, but retreat to Massachusetts during the summers. We have not been traveling unfortunately due to the pandemic as we love to visit new areas of the world and miss it, but we feel safe with our personal trainer, Crystal, who gets us out walking morning and evening for 3 to 4 miles a day. Crystal is a Keeshond 2 year old puppy.
Your grateful friends,
Dave and Charlotte
The Immune System, Darwin, and DNA
Editor’s Blog—February 21, 2021
My wife and I have been taking LDN preventively each night for some 20 years now, and we have hardly ever had a common cold during that time.
Could it be that the immune system, strengthened by LDN, is helping almost all of one’s tissues and organs avoid a gradual withering?
To learn more, read our LDN Editor’s Blog.
LDN: The Latest Research
The Journal of Translational Medicine—March 2018
LDN Causes Improvement and Remission in Inflammatory Bowel Disease Patients
Mitchell R. K. L. Lie, Janine van der Giessen, et al of the Department of Gastroenterology and Hepatology, Erasmus University Medical Centre, Rotterdam, report that low dose naltrexone induced clinical improvement in 74.5%, and remission in 25.5% of patients.
Click here to learn more.
LDN Documentary Returns
Norway TV2—October 2017
Norway TV2 Documentary: "Unknown Medicine LDN Gives Hope to Thousands of Patients."
Although the English language translation was lost to us for some time, we again have the great pleasure of being able to see the most absorbing video about LDN, now on YouTube. This Norwegian video (with English subtitles)—broadcast in 2013—tells an evenhanded and compelling story about the difficulties the population experienced in learning about LDN. It also highlights the success stories of several people with different diseases who were restored to good health through the use of LDN in Norway and in Ireland. By 2015, LDN users in Norway had increased from a mere 300 to about 15,000 people.
Latest News Concerning LDN
LDN Available to Treat Coronavirus—March 2020
Low dose naltrexone is a safe, inexpensive, readily available immune booster; anyone taking it receives a strengthened immune system. For those in fear of COVID-19 because they were in a high-risk category, taking daily LDN removes them from that group.
Click here to learn more.
"Wonder Drug" LDN
Could Help Treat Cancer, Multiple Sclerosis
CBS News Reports—February, 2008
JACKSONVILLE, FLA (CBS)—This report features an interview with Lori Miles, an MS sufferer who can now walk again, thanks to LDN. Also quoted in the piece is Dr. Daniel Kantor, neurologist and director of the Comprehensive Multiple Sclerosis Program at the Shands Jacksonville Neuroscience Institute: "I would like all of us to write to our congressmen, ask the FDA and NIH—National Institutes of Health—to fund more research about LDN."
Click here to view video.
First Study of LDN Published
in US Medical Journal
American Journal of Gastroenterology—January, 2007
Dr. Jill Smith’s original article, "Low-Dose Naltrexone Therapy Improves Active Crohn’s Disease," in the January issue of the American Journal of Gastroenterology (2007;102(4):820-8), officially presents LDN to the world of scientific medicine. Smith, Professor of Gastroenterology at Pennsylvania State University's College of Medicine, found that two-thirds of the patients in her pilot study went into remission and fully 89% of the group responded to treatment to some degree. She concluded that “LDN therapy appears effective and safe in subjects with active Crohn’s disease.” (For further information on Smith's study, please see the linked Clinical Trials page.)
Endoscopic Improvement in Crohn’s Colitis with Naltrexone
Figure A: Shown is the rectum of a subject with active Crohn’s Disease before starting therapy with naltrexone 4.5 mg/day. The mucosa is ulcerated, edematous, and inflamed.
Figure B: Shows the same area of the rectum in the same patient four weeks after naltrexone therapy. The lining is now healed, ulcers resolved, and the mucosa is healthy.
Copyrights: do not reproduce the above images and captions without written permission from Jill P. Smith, MD, Professor of Medicine, H-045 GI Division, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033
LDN a "Wonder Drug?"
ABC News Reports—May, 2008
By Ali Gorman
Hershey, Pa. - May 21, 2008 (WPVI) — It's a drug already helping thousands of people battle addiction, but many people believe it also has the potential to help tens-of-thousands of patients with diseases like Crohn's, multiple sclerosis, Lupus, Parkinson's and even HIV.
It's called low dose naltrexone or LDN. Many patients who've tried it said it works and doesn't have bad side effects. But getting it to a pharmacy near you could be difficult.
Click here to read more. (Video no longer available.)