LDN FILLERS

    If your Low Dose Naltrexone comes from a compounding
    pharmacy and arrives as a liquid, then you’re getting pure
    naltexone powder dissolved in distilled water.  This is probably
    the “purest” way to ingest naltrexone.  You don’t need to worry
    about fillers.

    BUT -- If you get your LDN in any other form, you're
    swallowing filler.

    A “filler” is an inert, inactive ingredient that accompanies every
    dose of naltrexone you take.  

    If you make your own LDN --

    If you make LDN by crushing ReVia (pronounced REV-yah)
    or another commercially manufactured 50mg naltrexone tablet,
    you're still injesting filler, because each tablet is comprised of
    about 16% Naltrexone and 84% filler.   

    What kind of filler is in your tablet?  This depends on the
    manufacturer.  Here are the main manufacturers:

    Barr Labs – Barr manufactures naltrexone under the brand
    name ReVia for the US and Canadian markets.  This tablet
    contains 50mg naltrexone and these inactive ingredients:  
    lactose monohydrate, colloidal silicone dioxide, magnesium
    stearate, crospovidone, microcrystalline cellulose, purified
    water, Opadry beige (coloring).  [Information from Barr Labs
    phone representative.]

    Bristol Myers Squibb – BMS manufactures naltrexone under
    the brand name ReVia in markets other than the US and
    Canada.  As of 2002, their 50 mg tablets contain 50 mg of
    naltrexone hydrochloride, plus these inactive ingredients (filler):
    lactose, microcrystalline cellulose, crospovidone, silicon
    dioxide, magnesium stearate, and pale yellow Opadry
    (colouring). [Information from a 2002 leaflet by Australian
    Prescription Products Guide.]  

    Mallinckrodt – makes a 50mg naltrexone pill called Depade.  
    This tablet contains 50mg naltrexone, plus these inactive
    ingredients (filler):   crospovidone, hydropropyl methylcellulose,
    lactose monohydrate, magnesium stearate, microcrystalline
    cellulose, polyethelene glycol, polysorbate 80, silicone dioxide,
    titanium dioxide, yellow iron oxide, and red iron oxide.  
    [Information from Mallinckrodt website.]

    [Historical Note:  The original ReVia was made by Dupont.  
    The inactive ingredients were:  lactose, microcrystalline
    cellulose, crospovidone, silicon dioxide, magnesium stearate,
    and pale yellow Opadry (colouring).  In 2001, Bristol Myers
    Squibb acquired DuPont Pharmaceuticals.  In April 2002,
    BMS sold the ReVia brand-name rights in the US and Canada
    to Barr Laboratories.  BMS continues to market ReVia outside
    of the US and Canada.]

    If your LDN is made by a compounding pharmacy –

    Ask your pharmacist how it is made.

    1.  Some compounders make LDN by crushing commercially
    manufactured 50mg tablets and putting the powder into
    capsules.  Because the amount of powder that goes into each
    capsule is not enough to fill the capsule, most pharmacies add
    additional filler.   If this is how you get your LDN, you can find
    out which commercially manufactured tablet is being used and
    what kind of additional filler is being added.   

    2.  Other compounders don’t crush 50mg tablets; instead, they
    use pure naltrexone powder (purchased in bulk from
    pharmaceutical companies), which they mix with filler.  From
    these pharmacists, you can learn what kind of filler you are
    taking.  

    Here are some of the most common fillers used by
    compounding pharmacists:

    LACTOSE:   Lactose is a naturally-occurring simple
    carbohydrate, or sugar, found only in the milk of mammals. For
    this reason, it is also commonly referred to as “milk sugar.”

    Lactose has long been used as a soluble filler in the manufacture
    of orally administered pharmaceuticals.  It is safe, stable,
    inexpensive, and has a fast dissolution rate.   Pharmaceutical-
    grade lactose powder is highly pure, and specifically produced
    to meet government standards of safety and purity.

    Lactose is easily tolerated by most patients.  However, if you
    are lactose-intolerant (that is, if milk products give you nausea,
    diarrhea, abdominal cramping, bloating, or flatulence), you
    might want to try another filler.

    Note:  Dr Bihari asks his patients to use lactose, unless they
    have an adverse reaction… not because he believes lactose is
    better than other fillers, but because he began his study of LDN
    with lactose, and he wants his records to be consistent.    

    ACIDOPHILOUS – (pronounced Ah-SID-uh-FILL-us) – is
    lactic bacteria, or one-celled micro-organisms, used by the
    body to promote immunity and proper nutrition.  Sold over the
    counter as a nutritional supplement and digestive aid,  
    Acidophilus is sometimes used as a treatment for diarrhea and
    constipation.  It is commercially available as powder, tablets,
    capsules or liquid.

    Lactose-intolerant patients sometimes switch to Acidophilus
    filler in their LDN capsules.

    AVICEL – a brand name for microcrystalline cellulose.  Avicel
    has been used safely and effectively for 35 years in the food
    and pharmaceutical industries.  Virtually inert, it is not absorbed
    into the system, and will not interfere or interact with other
    nutrients, vitamins or minerals.   Avicel is made of wood which
    has been purified and powdered into extremely tiny particles --
    between 0.000039 and 0.0001560 of an inch of pure fiber,
    with the consistency of a very fine face powder.  

    Avicel is the filler used by Skip’s Pharmacy in Boca Raton.   
    For a fun history of Avicel, “Let Us Have Nothing To Eat,”
    CLICK HERE.

    CALCIUM CARBONATE – a mineral that occurs naturally
    in limestone, marble and coral.  Crushed to a fine, flavorless,
    odourless powder, it is a natural food additive, and the most
    common ingredient in calcium supplements and antacids.

    Calcium is absorbed by the small intestine and is used by the
    body to build bone tissue.  Calcium supplements are generally
    well tolerated, but in some patients may cause constipation,
    bloating, gas and flatulence.  

    People with kidney stones, hypercalcemia, sarcoidosis,
    hyperparathyroidism, hypervitaminosis D or cancer should not
    take calcium carbonate.

    People taking calcium supplements are usually advised to take
    them with food.  

    There has been some concern among LDN users that calcium
    carbonate is occasionally packed too tight in the capsule, which
    can cause a slow-release reaction, rather than the desired fast-
    release.

Any questions about filler should be referred to your
doctor or your pharmacist.

                                                 -- Last updated 1/7/06
      

    Copyright 2005 by Gazorpa.com.   

    [Note:  The information provided on this site is intended for educational and
    informational purposes only.  Gazorpa.com is not engaged in rendering
    medical service or advice, and the information provided is not a substitute for
    a professional medical opinion. If you have a medical problem, please contact
    a qualified health professional.]


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